Gurps is fun but takes too long to create a character and learn the in's and out's if you've never played before.
I have played GURPS, Vampire the Masquerade, AD&D, AD&D 2e, D&D 3.0 and 3.5, Star Wars Revised Ed., Star Wars Saga Ed, Shadow Run, Mech Warrior and a few others that I can't think of right now.
Dice Usage: (ordered from least to most):
Star Wars Saga Edition
GURPS
D&D (no wizards in your party)
Vampire
D&D (wizards in your party)
I have the longest standings playing D&D and Star Wars. The fun-factor and ease of rules of the d20 system cannot be under-stated. Players and GM's alike can pick up the books, read through it once, and learn the system really quickly. The biggest drawback to D&D is that there are tons of sourcebooks which can mean $$$ if you wanna keep up. Plus, every few years they change editions. The benefit, though, is if you decide to go with a slightly older edition (like D&D 3.5 or Star Wars Saga Ed. instead of D&D 4.0 and SW Edge of the Empire) you can find all or nearly all of the sourcebooks online as PDFs as well as tons of premade adventures.
Vampire and GURPS have very loose rules giving GM's more flexibility, but going from one GM to another can look incredibly different and have totally different feels. It has more of a "house rules" feel to it than a rigid system.
Mech Warrior has a ton of rules that you need to learn before you can really get going.