The problem with drugs is really not the drugs themselves. We’ve already got so many legal things that people use that cause altered brain states and have associated health risks (tobacco, alcohol, inhalants, the “bath salts” that krellin mentioned, salvia, synthetic marijuana, etc.) that it is the height of hypocrisy to take the moral high ground against other substances that are really not much different from the legal ones (and kill far, far, fewer people).
The problem with drugs is drug-related violence and the overcrowding of our prisons with people incarcerated, in many cases, for merely possessing small amounts of illegal narcotics with no intent of selling them. Gangs kill each other and innocent bystanders on the streets because they are fighting over territory- territory to distribute drugs in. If these drugs were legal, the gangs would fall apart, because no such convoluted network of submarines, private planes, smugglers, middlemen, dealers, and enforcers could ever compete with the USPS and the corner grocery. It’d be a lot safer to walk the streets in any city, tens of thousands would not be slaughtered in other countries and our own as part of drug wars, and we could lower our incarceration rate from its dizzying heights.
Surprising, isn’t it, that despite denouncing other countries for being authoritarian and imprisoning people unjustly, we incarcerate a larger percentage of our population than North Korea, China, Cuba, Syria, Iran, Saudi Arabia, and every other country in the entire world. Legalizing drugs might start to fix that.