@Alderian:
Actually, watch those last 5 episodes...they all make a good, long, last story arc together...
The finale might be OK by itself, but without that arc...yeah, there's a couple things you need to know going in, and besides, the whole thing builds and builds (the penultimate episode, actually, last week was such a great one I wondered how they could top the situation they left them all in, and a couple before that, we get another great House/Wilson "roadtrip" episode, which was great when they did it with the Coma Guy and probably the only good thing to come out of Season 5, that roadtrip in that one and the story we get as to how Wilson and House first met.)
So yeah--have a mini-marathon night, or space them out, serial-style, one night over 5 days or so, but I'd recommend watching all those last 4 or 5 leading up to the finale.
@semck:
Well, I immediately said "Well, either this is ___ or they're pulling another Holmes reference here to ___"...
I don't know if it's too obvious, I guess, watch it and then tell me if that totally ruined it? (If so, sorry--I'm just an ass, I guess...ah, my favorite ass on TV is now retired...I went through high school and community college with this show, it'll feel weird, not having it on live, but oh well--as TNG's great finale says, "All Great Things...")